Binghamton professor to use NIH grant to explore serotonin’s role in Parkinson’s disease

VESTAL, N.Y. — A Binghamton University professor will use federal funding for research into serotonin’s role in Parkinson’s disease.

When he came to Binghamton in 2005, Christopher Bishop, a psychology professor, uncovered something interesting in his research. He found that the serotonin system, best known for its influence on mood and motivation, also plays a role in the regulation of movement, according to a university news release.

That discovery led to pharmacological research that could lead to better treatments for patients with Parkinson’s disease. But the problem is the research field has “long neglected” how serotonin neuroplasticity in Parkinson’s disease becomes a central driver for motion, the university said.

The five-year, $3.2 million grant from the National Institutes of Health (NIH) will help address that knowledge gap, Binghamton University said.

Other researchers involved with the project include Fredric Manfredsson, an associate professor and a molecular biologist and expert in genetic strategies at the Barrow Neurological Institute in Phoenix, Arizona, and Kuei-Yuan Tseng, a professor and an internationally known neurophysiologist at the University of Illinois–Chicago.

“We started by looking at how drugs affected the Parkinsonian phenotype and found some really interesting effects but didn’t understand all of the effects we were seeing,” Bishop said in the release. “What this grant is doing is saying, ‘Let’s take a step back and use modern technologies to dissect the neuro-circuits and better understand the mechanisms that are involved in this neuroplasticity.’”

More on the research

The serotonin system appears to function as a secondary system when it comes to movement. In healthy individuals, it plays a minor role, but Bishop’s work suggests it may function as a surrogate for regulating movement in patients with mid- to late-stage Parkinson’s disease.

Not only does it appear to take over for the pathological loss of dopamine cells, but it may even convey the therapeutic benefits of the primary medication for Parkinson’s disease, L-DOPA.

While L-DOPA remains the “gold-standard” of treatment for Parkinson’s disease, nearly 90 percent of patients using the drug develop abnormal involuntary movements, or L-DOPA-induced dyskinesias (LID), within a decade. That severely affects their quality of life. Research points to brain serotonin neurons as a central cause of these movements.

Treatments have been developed that alleviate dyskinesias, but only a minority of patients have benefited due to their cost, side effects, or invasiveness. Researchers have yet to find a way to prevent the development of LID, partly because they don’t know precisely how L-DOPA treatment instigates maladaptive reorganization of these serotonin neurons.

Bishop and his research team have collected preliminary data from human post-mortem tissue that provides “exciting new insights” into the mechanisms behind serotonin neuroplasticity, Binghamton University said. Understanding these mechanisms “could ultimately lead” to treatments that delay or reduce L-DOPA side effects while maintaining its benefits.

“Movement is such an important feature of our survival and our ability to flourish. If we lose movement, evolutionarily, we’re done,” Bishop said. “So there must be these backup systems that come into play. I think what we’re seeing in Parkinson’s disease is the ability of these circuits to rewire sufficiently so that they continue to foster movement and survival.”